Affordable Access

deepdyve-link
Publisher Website

Molecular evolution and selection pressure analysis of infectious hematopoietic necrosis virus (IHNV) revealed the origin and phylogenetic relationship of Iranian isolates in recent epidemics in Iran.

Authors
  • Jalali, Seyed Amir Hossein1
  • Mohammadinezhad, Rezvan2
  • Mohammadi, Ashraf3
  • Latifian, Mohamad Hassan4
  • Talebi, Majid5
  • Soleimanin-Zad, Sabihe6
  • Golkar, Pouran2
  • Hemmatzadeh, Farhid7
  • 1 Research Institute for Biotechnology and Bioengineering, Isfahan University of Technology, Isfahan, 84156-83111, Iran; Department of Natural Resources, Isfahan University of Technology, Isfahan, 84156-83111, Iran. Electronic address: [email protected] , (Iran)
  • 2 Research Institute for Biotechnology and Bioengineering, Isfahan University of Technology, Isfahan, 84156-83111, Iran. , (Iran)
  • 3 Human Viral vaccine Department, Razi Vaccine and Serum Research Institute (RVSRI), Hessark Karadj Agricultural Research, Education and Extension Organization (AREEO), Tehran, Iran. , (Iran)
  • 4 Department of Agricultural Biotechnology, College of Agriculture, Isfahan University of Technology, Isfahan, 8415683111, Iran. , (Iran)
  • 5 Research Institute for Biotechnology and Bioengineering, Isfahan University of Technology, Isfahan, 84156-83111, Iran; Department of Agricultural Biotechnology, College of Agriculture, Isfahan University of Technology, Isfahan, 8415683111, Iran. , (Iran)
  • 6 Research Institute for Biotechnology and Bioengineering, Isfahan University of Technology, Isfahan, 84156-83111, Iran; Department of Food Science and Technology, College of Agriculture, Isfahan University of Technology, Isfahan, Iran. , (Iran)
  • 7 School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, SA, Australia. , (Australia)
Type
Published Article
Journal
Virology
Publisher
Elsevier
Publication Date
Jun 27, 2019
Volume
535
Pages
45–58
Identifiers
DOI: 10.1016/j.virol.2019.06.012
PMID: 31272011
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Infectious hematopoietic necrosis virus (IHNV) is the causative agent for a lethal salmonid disease. In this study, we surveyed the IHNV's epidemiology, diversity and the origin of infection in Iran. Phylogenetic analysis revealed that Iranian isolates belonged to one of the two lineages of E genogroup. Subsequently, a combination of phylogenetic, antigenic and structural analysis was performed to investigate the evolution of E genogroup lineages. Site-specific analysis of the viral glycoprotein showed different co-evolving and positively selected sites in each lineage. Most of these sites were mapped to the predicted antigenic patches of the glycoprotein. Further characterization revealed E lineages can be differentiated, in part, by specific mutations at positions 91 and 130, which are located in the structurally flexible regions of the glycoprotein, suggesting a key adaptative role for these sites. These data may assist in better monitoring the emerging isolates in regions infected to IHNV from E genogroup. Copyright © 2019 Elsevier Inc. All rights reserved.

Report this publication

Statistics

Seen <100 times