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The molecular evolution of neuropeptides: prospects for the '90s.

Authors
  • Dores, R M1
  • McDonald, L K
  • Steveson, T C
  • Sei, C A
  • 1 University of Denver, Department of Biological Sciences, Colorado.
Type
Published Article
Journal
Brain, behavior and evolution
Publication Date
Jan 01, 1990
Volume
36
Issue
2-3
Pages
80–99
Identifiers
PMID: 2176909
Source
Medline
License
Unknown

Abstract

Three distinct opioid precursors have been identified in the central nervous system of mammals: proopiomelanocortin (POMC), proenkephalin, and prodynorphin. These precursors are derived from separate genes, synthesized in distinct neurons, and yield unique sets of opioid end products. This review will discuss the general mechanisms involved in the biosynthesis of neuropeptide precursors and consider the roles of posttranscriptional and posttranslational processing mechanisms in the generation of multiple sets of end products from a single gene. In addition, techniques that can be used for isolating and characterizing neuropeptide genes, mRNAs, and end products will be reviewed. These introductory comments will serve as the framework for a discussion of the phylogeny of the opioid precursors in the major groups of non-mammalian vertebrates.

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