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The Molecular Determinants of Mitochondrial Membrane Contact With ER, Lysosomes and Peroxisomes in Neuronal Physiology and Pathology.

Authors
  • Liao, Yajin1
  • Dong, Yuan2
  • Cheng, Jinbo1
  • 1 Center on Translational Neuroscience, College of Life & Environmental Science, Minzu University of China, Beijing, China. , (China)
  • 2 Department of Biochemistry, Medical College, Qingdao University, Qingdao, China. , (China)
Type
Published Article
Journal
Frontiers in Cellular Neuroscience
Publisher
Frontiers Media SA
Publication Date
Jan 01, 2020
Volume
14
Pages
194–194
Identifiers
DOI: 10.3389/fncel.2020.00194
PMID: 32848610
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Membrane tethering is an important communication method for membrane-packaged organelles. Mitochondria are organelles with a bilayer membrane, and the membrane contact between mitochondria and other organelles is indispensable for maintaining cellular homeostasis. Increased levels of molecular determinants that mediate the membrane contact between mitochondria and other organelles, and their functions, have been revealed in recent years. In this review article, we aim to summarize the findings on the tethering between mitochondria and other organelles in physiological or pathological conditions, and discuss their roles in cellular homeostasis, neural activity, and neurodegenerative diseases. Copyright © 2020 Liao, Dong and Cheng.

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