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The molecular complexity of glucocorticoid actions in inflammation - a four-ring circus.

Authors
  • Goulding, Nicolas J1
  • 1 William Harvey Research Institute, Barts and the London, Queen Mary's School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK. [email protected]
Type
Published Article
Journal
Current Opinion in Pharmacology
Publisher
Elsevier
Publication Date
Dec 01, 2004
Volume
4
Issue
6
Pages
629–636
Identifiers
PMID: 15525555
Source
Medline
License
Unknown

Abstract

Glucocorticoids have been the mainstay of anti-inflammatory therapy for the past 50 years despite the significant risks associated with their long-term use. Recent research into the molecular mechanisms of action of these compounds can be aggregated into two major themes: first, those that focus on the involvement of the glucocorticoid receptor in regulating the transcription of pro-inflammatory genes; and second, studies that seek to identify alternative pathways of glucocorticoid action either via the induction of anti-inflammatory mediators or through rapid non-genomic mechanisms. Understanding the temporal-spatial patterns of these multiple mechanisms on relevant cell types will be key to explaining the profound effects that these four-ring steroids exert on the inflammatory process.

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