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Molecular cloning of TOPAP: a topographically graded protein in the developing chick visual system.

Authors
  • Savitt, J M
  • Trisler, D
  • Hilt, D C
Type
Published Article
Journal
Neuron
Publisher
Elsevier
Publication Date
Feb 01, 1995
Volume
14
Issue
2
Pages
253–261
Identifiers
PMID: 7857637
Source
Medline
License
Unknown

Abstract

Topographically graded molecules representing position-specific differences among otherwise similar cells are thought to play a role in the patterning of the developing nervous system. In the embryonic chick visual system, a 40 kDa protein, TOPAP, is expressed in a posterior > anterior gradient in the retina and in an inverted anterior > posterior gradient in the optic tectum, the major retinal projection area. Here we report the isolation and nucleotide sequencing of a complementary DNA clone encoding the chick TOPAP protein and demonstrate that the mRNA encoding this coiled-coil integral membrane protein is topographically graded within the retina and is present in a variety of chick tissues.

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