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Molecular characterization of hepatitis A outbreak in the province of Rome, Lazio region, Italy, January–July 2013

Authors
  • Capobianchi, Maria R.
  • Garbuglia, Anna Rosa
  • Agrati, Chiara
  • Rianda, Alessia
  • Noto, Pasquale
  • Corpolongo, Angela
  • Cataldo, Maria Adriana
  • Rosati, Silvia
  • Zaccaro, Paola
  • Loffredo, Mariarosaria
  • Pompa, Maria Grazia
  • Girardi, Enrico
  • Scognamiglio, Paola
  • Ippolito, Giuseppe1, 2, 3, 4, 5, 6, 7, 2, 8, 2
  • 1 Laboratory of Virology
  • 2 National Institute for Infectious Diseases “L. Spallanzani”
  • 3 Local Health Unit ASL Roma D
  • 4 Ministry of Health
  • 5 DG for Prevention
  • 6 V Office
  • 7 Department of Epidemiology
  • 8 Scientific Direction
Type
Published Article
Journal
Microbes and Infection
Publisher
Elsevier
Publication Date
Jan 01, 2014
Accepted Date
Jan 21, 2014
Identifiers
DOI: 10.1016/j.micinf.2014.01.003
Source
Elsevier
Keywords
License
Unknown

Abstract

Reduced circulation of hepatitis A virus lead to an increase of susceptible individuals, and outbreaks occurred recently. In Northern Italy an outbreak is ongoing, attributed to a monophyletic genotype IA strain, with mixed frozen berries as probable source. From 01/01/2013 to 07/15/2013, 30 cases were diagnosed at National Institute for Infectious Diseases, Rome, Italy, representing about twice the number of cases in whole 2012. Phylogenetic analysis indicated that most, although not all, infections were attributable to the same monophyletic genotype IA strain identified in the contemporary Northern Italy outbreak. This strain is also very similar to previous isolates from Venezuela.

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