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Molecular chaperones regulate p53 and suppress senescence programs.

Authors
  • Sherman, Michael Y
  • Sherman, Michael
  • Gabai, Vladimir
  • O'Callaghan, Cornelia
  • Yaglom, Julia
Type
Published Article
Journal
FEBS Letters
Publisher
Wiley (John Wiley & Sons)
Publication Date
Jul 31, 2007
Volume
581
Issue
19
Pages
3711–3715
Identifiers
PMID: 17555746
Source
Medline
License
Unknown

Abstract

Many types of cancer cells constitutively express major molecular chaperones at high levels. Recent findings demonstrate that specific depletion of individual chaperones, including various members of the Hsp70 family, small heat shock proteins, or VCP/p97, leads to activation of p53 pathway and subsequently triggers cellular senescence. Here, we discuss a possibility that in cancer cells high levels of chaperones serve to keep the p53 signaling under control, thus allowing cancer cells to evade the default senescence and form tumors.

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