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Molecular and cellular radiobiological effects of Auger emitting radionuclides.

Authors
  • Kassis, Amin I1
  • 1 Department of Radiology, Harvard Medical School, 200 Longwood Avenue, Armenise Building Room D2-137, Boston, MA 02115, USA. [email protected]
Type
Published Article
Journal
Radiation Protection Dosimetry
Publisher
Oxford University Press
Publication Date
Feb 01, 2011
Volume
143
Issue
2-4
Pages
241–247
Identifiers
DOI: 10.1093/rpd/ncq385
PMID: 21106639
Source
Medline
License
Unknown

Abstract

Although the general radiobiologic principles underlying external beam therapy and radionuclide therapy are similar, significant differences in the biophysical and radiobiologic effects from the two types of radiation continue to accumulate. Here, I will address the unique features that distinguish the molecular and cellular radiobiological effects of Auger electron-emitting radionuclides consequent to (1) the physical characteristics of the decaying atom and its subcellular localisation, (2) DNA topology and (3) the bystander effect. Based on these experimental findings, I postulate that the ability of track structural simulations as primary tools in modelling DNA damage and cellular survival at the molecular level would be greatly enhanced when these contributions are factored in.

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