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Molecular and Biological Functions of Melatonin in Endometrial Cancer.

Authors
  • Dana, Parisa Maleki1
  • Sadoughi, Fatemeh1
  • Mobini, Moein2
  • Shafabakhsh, Rana1
  • Chaichian, Shala3
  • Moazzami, Bahram3
  • Chamani, Maryam4
  • Asemi, Zatollah1
  • 1 Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran. , (Iran)
  • 2 Faculty of Kinesiology, University of Calgary, Calgary, AB, Canada. , (Canada)
  • 3 Pars Advanced and Minimally Invasive Medical Manners Research Center, Pars Hospital, Iran University of Medical Sciences, Tehran, Iran. , (Iran)
  • 4 Department of Gynecology and Obstetrics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. , (Iran)
Type
Published Article
Journal
Current drug targets
Publication Date
Jan 01, 2020
Volume
21
Issue
5
Pages
519–526
Identifiers
DOI: 10.2174/1389450120666190927123746
PMID: 31560286
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Endometrial cancer is the fifth leading cancer among women. This rate is higher in developed countries and its incidence is increasing worldwide. Diabetes mellitus, obesity, hypertension and arteriosclerosis are major risk factors for endometrial cancer. Melatonin is a hormone synthesized in the pineal and extra-pineal organs such as the digestive tract, bone marrow, retina and more. Evidence shows the potential effects of melatonin in endometrial cancer inhibition. Therefore, the focus of this paper is to review this outstanding evidence and to summarize the molecular and biological mechanisms of melatonin for the inhibition of endometrial cancer. Copyright© Bentham Science Publishers; For any queries, please email at [email protected]

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