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A molecular basis for target-cell toxicity and upper urothelial carcinoma in analgesic abusers and patients with Balkan endemic nephropathy.

Authors
Type
Published Article
Journal
IARC scientific publications
Publication Date
Issue
115
Pages
215–227
Identifiers
PMID: 1820336
Source
Medline
License
Unknown

Abstract

Ochratoxin A is ubiquitous in regions where Balkan endemic nephropathy is common. It damages the kidney cortex in a range of experimental animals and induces renal parenchymal carcinoma in mice, but it is not a potent carcinogen, nor is there experimental evidence to link it to upper urothelial carcinoma (UUC). A model UUC can be induced experimentally in rodents by urothelial initiation, followed by an acutely induced papillary necrosis. This two-stage experimental model may help to clarify the role of ochratoxin A in initiating or promoting upper urothelial cells and increase our understanding of the development of UUC in patients with Balkan endemic nephropathy.

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