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Molecular basis of intervertebral disc degeneration and herniations: what are the important translational questions?

Authors
  • Kadow, Tiffany
  • Sowa, Gwendolyn
  • Vo, Nam
  • Kang, James D
Type
Published Article
Journal
Clinical Orthopaedics and Related Research
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Jun 01, 2015
Volume
473
Issue
6
Pages
1903–1912
Identifiers
DOI: 10.1007/s11999-014-3774-8
PMID: 25024024
Source
Medline
License
Unknown

Abstract

Intervertebral disc degeneration occurs where there is a loss of homeostatic balance with a predominantly catabolic metabolic profile. A basic understanding of the molecular changes occurring in the degenerating disc is important for practicing clinicians because it may help them to inform patients to alter lifestyle choices, identify beneficial or harmful supplements, or offer new biologic, genetic, or stem cell therapies.

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