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The molecular basis of DNA-protein recognition inferred from the structure of cro repressor.

Authors
  • Ohlendorf, D H
  • Anderson, W F
  • Fisher, R G
  • Takeda, Y
  • Matthews, B W
Type
Published Article
Journal
Nature
Publication Date
Aug 19, 1982
Volume
298
Issue
5876
Pages
718–723
Identifiers
PMID: 6213863
Source
Medline
License
Unknown

Abstract

Recognition by cro repressor protein of its specific DNA binding sites appears to occur via multidentate hydrogen bonds between amino acid side chains of the protein and base-pair atoms in the major groove of right-handed B-form DNA. Most of the sequence-specific interactions between cro and DNA, as well as a number of sequence-independent ones, are mediated by a two-alpha-helical unit which appears to be common to many proteins that regulate gene expression.

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