Affordable Access

Molecular aspects of neuro-oncology.

Authors
  • Santarius, T
  • Kirsch, M
  • Rossi, M L
  • Black, P M
Type
Published Article
Journal
Clinical Neurology and Neurosurgery
Publisher
Elsevier
Publication Date
Aug 01, 1997
Volume
99
Issue
3
Pages
184–195
Identifiers
PMID: 9350399
Source
Medline
License
Unknown

Abstract

Detailed understanding of molecular events responsible for brain tumor growth is a prerequisite for the development of effective therapeutic modalities leading to improved prognosis and cure. Advances in molecular biology in the past decades have revolutionized our understanding of cancer, including brain tumors. We have learned that abnormal proliferation, inability of the cells to die and their potential to modify their tissue environment result from accumulation of genetic aberrations. This article reviews genetic mechanisms implicated in the pathogenesis of nervous system tumors, such as unactivation of tumor suppressor and replication error genes, generation of abnormal growth factor loops, alterations of apoptotic pathways and angiogenesis.

Report this publication

Statistics

Seen <100 times