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Modulatory action of combined treatment with antibodies against S100 protein and low doses of this protein on membrane effects of quinine.

Authors
Type
Published Article
Journal
Bulletin of experimental biology and medicine
Publication Date
Volume
142
Issue
1
Pages
1–4
Identifiers
PMID: 17369887
Source
Medline
License
Unknown

Abstract

Antibodies against calcium-binding protein S100 (AB-S100) 1.5-fold increased, while quinine 2-fold decreased the frequency of action potential generation in B4 and B6 neurons. Application of quinine against the background of AB-S100 treatment returned this parameter to the initial level. Pretreatment with AB-S100 in low doses prevents changes the frequency of action potential generation induced by application of AB-S100 in the initial dilution. The duration of action potential increased by 1.6 times after application of AB-S100 and quinine, while after application of quinine increased this parameter by more than 6 times. AB-S100 decreased maximum inward current by 20%. Our experiments demonstrated a modulating effect of combined administration of AB-S100 and its low doses on the membrane effects of quinine.

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