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Modulation of presynaptic cholinergic receptors by adrenergic drugs.

Authors
Type
Published Article
Journal
Bollettino della Società italiana di biologia sperimentale
Publication Date
Volume
59
Issue
2
Pages
171–175
Identifiers
PMID: 6860490
Source
Medline
License
Unknown

Abstract

Some adrenergic drugs were tested for their ability to interact with the stimulatory activity of scopolamine on Ach output from brain cortex. The noradrenergic neurotoxin DSP4 was the most potent in depressing the effect of the anticholinergic drug and behaved like a potent alpha 2-agonist and alpha 1-antagonist on nervous peripheral structures. This finding supports the view of a connection between presynaptic adrenergic and muscarinic receptors.

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