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Modulation of plasminogen activator activity in human skin fibroblasts infected with mycoplasmas.

Authors
Type
Published Article
Journal
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
Publication Date
Volume
173
Issue
3
Pages
324–327
Identifiers
PMID: 6683407
Source
Medline
License
Unknown

Abstract

Secreted and cell-associated plasminogen activator was measured in human skin fibroblasts infected with mycoplasmas. The infected fibroblasts exhibited significantly higher levels of secreted and cell-associated plasminogen activator activity compared to uninfected skin fibroblasts. Subconfluent infected fibroblasts had increased plasminogen activator activity compared to confluent infected fibroblasts. Plasminogen activator may be important in tissue destruction in disease states in which mycoplasma infection has been implicated.

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