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Modulation of peripheral-type benzodiazepine receptor levels in a reperfusion injury pig kidney-graft model.

Authors
  • Hauet, Thierry
  • Han, Zeqiu
  • Wang, Yan
  • Hameury, Frederic
  • Jayle, Christophe
  • Gibelin, Helene
  • Goujon, Jean Michel
  • Eugene, Michel
  • Papadopoulos, Vassilios
Type
Published Article
Journal
Transplantation Journal
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Dec 15, 2002
Volume
74
Issue
11
Pages
1507–1515
Identifiers
PMID: 12490782
Source
Medline
License
Unknown

Abstract

This study indicates that PBR expression correlates with the quality of kidney preservation and might serve as an index of kidney and mitochondria viability. Moreover, these data suggest that PBR might be involved in membrane biogenesis during reperfusion. In addition, considering the identical localization of PBR in human and pig kidneys, these findings could have a direct application in human clinical settings of kidney pathology.

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