Affordable Access

Modulation of the microtubule cytoskeleton: a role for a divergent canonical Wnt pathway.

Authors
Type
Published Article
Journal
Trends in Cell Biology
0962-8924
Publisher
Elsevier
Publication Date
Volume
17
Issue
7
Pages
333–342
Identifiers
PMID: 17643305
Source
Medline
License
Unknown

Abstract

Wnts are signalling molecules implicated in normal development and in disease. Although Wnts can signal through three pathways, the canonical or beta-catenin pathway has been particularly studied because of its crucial role in embryonic patterning and cancer. It is well accepted that canonical Wnt signalling regulates gene expression by modulating the levels of beta-catenin, a co-activator of Tcf/Lef transcription factors. However, a divergent canonical Wnt pathway directly regulates the microtubule cytoskeleton. Interestingly, many components of the pathway are associated with the cytoskeleton and can act locally. Here I discuss recent evidence supporting a direct role for canonical Wnt signalling in microtubule regulation, and how this function sheds a new light into the mechanisms that regulate cell-fate determination and polarization.

Statistics

Seen <100 times