Affordable Access

[Modulation of lymphocytes and immunoglobulins by serine proteinase of Staphylococcus aureus].

Authors
  • Porwit-Bóbr, Z
Type
Published Article
Journal
Medycyna doświadczalna i mikrobiologia
Publication Date
Jan 01, 1993
Volume
45
Issue
1
Pages
37–40
Identifiers
PMID: 8231440
Source
Medline
License
Unknown

Abstract

Serine proteinase of S. aureus binds with surface of peripheral blood lymphocytes and by proteolysis of polypeptides on the membrane and transduction of signals, changes in polyclonal activation of T and B lymphocytes occur. Cleavage of immunoglobulins tested in three classes and evaluated by electrophoresis in polyacrylamide gel (SDS-Page) of Ig fragments, was differing. IgG and IgG fragments were degraded in higher degree than IgM, H and L chains or i Fc and i Fab fragments. Influence of proteolytic modulation of IgG particles on fixation antigenic fractions homogenized by ultrasound cells of S. aureus was evaluated in ELISA test. Basing on detailed results postulated mechanism of modification effect of immunoglobulins and lymphocyte reaction under influence of serine proteinase of S. aureus in microenvironment of after-inflammatory reaction in staphylococcal infection, has been accepted.

Report this publication

Statistics

Seen <100 times