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[Modulation of the expression of histocompatibility antigens class I (HLA-A,B,C) in the human pancreas].

Authors
Type
Published Article
Journal
Bollettino della Società italiana di biologia sperimentale
Publication Date
Volume
65
Issue
3
Pages
187–194
Identifiers
PMID: 2569881
Source
Medline

Abstract

In this study the expression of HLA class I molecules was analysed on caudal portions of ten pancreata from cadaver donors by means of indirect immunoperoxidase and immunophosphatase techniques. In 7 out of ten pancreata the results showed that islets tissue was almost negative for the expression of HLA Class I antigens as opposed to exocrine tissue that appeared positive. Within exocrine tissue and large sized islets strongly positive interstitial cells were also detected. Double stainings showed that the strongly positive interstitial cells expressed also Leu M1 antigens. Preliminary studies on the remaining three pancreata demonstrate an increase of hematic interstitial cells together with a parallel increase of HLA class I antigens by endocrine parenchyma. The above data suggest that an increase of interstitial cells within pancreas may influence islets antigenicity.

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