Modulation of the effect of vascular endothelial growth factor on endothelial cells by heparin: critical role of nitric oxide-mediated mechanisms.
- Published Article
Journal of nephrology
- Publication Date
Jan 01, 2005
HMWH and LMWH block the proliferative and [Ca2+]i-mobilizing effects of VEGF on EC, by a NO-dependent mechanism. On the contrary, VEGF-induced NO production is stimulated. The Akt/PI3K pathway at least in part mediates this effect. By changing the way the VEGF intracellular signaling is driven, heparin could act as a stabilizing factor for the endothelium, without stimulating vessel proliferation.
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This record was last updated on 07/03/2016 and may not reflect the most current and accurate biomedical/scientific data available from NLM.
The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/16013009