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Modulation of the effect of vascular endothelial growth factor on endothelial cells by heparin: critical role of nitric oxide-mediated mechanisms.

Authors
  • Yagüe, Susana
  • Alvarez Arroyo, Victoria
  • Castilla, Angeles
  • González Pacheco, Francisco R
  • Llamas, Pilar
  • Caramelo, Carlos
Type
Published Article
Journal
Journal of nephrology
Publication Date
Jan 01, 2005
Volume
18
Issue
3
Pages
234–242
Identifiers
PMID: 16013009
Source
Medline
License
Unknown

Abstract

HMWH and LMWH block the proliferative and [Ca2+]i-mobilizing effects of VEGF on EC, by a NO-dependent mechanism. On the contrary, VEGF-induced NO production is stimulated. The Akt/PI3K pathway at least in part mediates this effect. By changing the way the VEGF intracellular signaling is driven, heparin could act as a stabilizing factor for the endothelium, without stimulating vessel proliferation.

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