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Modulating ICBP90 to suppress human ribonucleotide reductase M2 induction restores sensitivity to hydroxyurea cytotoxicity.

Authors
  • Un, Frank
  • Qi, Christina
  • Prosser, Megan
  • Wang, Norby
  • Zhou, Bingsen
  • Bronner, Christian
  • Yen, Yun
Type
Published Article
Journal
Anticancer research
Publication Date
Jan 01, 2006
Volume
26
Issue
4B
Pages
2761–2767
Identifiers
PMID: 16886595
Source
Medline
License
Unknown

Abstract

A transcriptional intervention strategy is presented through which HU-resistant cancers may be eradicated without dose escalation.

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