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Modulating aβ33-42 peptide assembly by graphene oxide.

Authors
  • Li, Qiang
  • Liu, Lei
  • Zhang, Shuai
  • Xu, Meng
  • Wang, Xueqin
  • Wang, Chen
  • Besenbacher, Flemming
  • Dong, Mingdong
Type
Published Article
Journal
Chemistry - A European Journal
Publisher
Wiley (John Wiley & Sons)
Publication Date
Jun 09, 2014
Volume
20
Issue
24
Pages
7236–7240
Identifiers
DOI: 10.1002/chem.201402022
PMID: 24838837
Source
Medline
Keywords
License
Unknown

Abstract

Graphene oxide (GO) is utilized as the modulator to tune the formation and development of amyloid fibrils (Aβ33-42 ). Atomic force microscopy temporal evolution measurements reveal that the initial binding between the peptide monomer and the large available surface of the GO sheets can redirect the assembly pathway of amyloid beta. The results support the possibility to develop graphene-based materials to inhibit amyloidosis.

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