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Modular Approach to the Functionalization of Polymersomes.

Authors
  • Rijpkema, Sjoerd J1
  • Langens, Sabine G H A1
  • van der Kolk, Marnix R1
  • Gavriel, Katerina1
  • Toebes, B Jelle1
  • Wilson, Daniela A1
  • 1 Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands. , (Netherlands)
Type
Published Article
Journal
Biomacromolecules
Publisher
American Chemical Society
Publication Date
May 11, 2020
Volume
21
Issue
5
Pages
1853–1864
Identifiers
DOI: 10.1021/acs.biomac.9b01734
PMID: 32032491
Source
Medline
Language
English
License
Unknown

Abstract

Functionalizing polymersomes remains a challenge due to the limitation in reaction conditions applicable to the chemistry on the surface, hindering their application for selective targeting. In order to overcome this limitation, functionalization can be introduced right before the self-assembly. Here, we have synthesized a library (32 examples) of PEG-b-PS and PEG-b-PDLLA with various functional groups derived from the amine-functionalized polymers, leading to functionally active polymersomes. We show that polymersome formation is possible via the general method with all functionalized groups and that these handles are present on the surface and are able to undergo reactions. Additionally, this methodology provides a general synthetic tool to tailor the functional group of the polymersome right before self-assembly, without limitation on the reaction conditions.

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