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A modified vaccinia Ankara vector-based vaccine protects macaques from SARS-CoV-2 infection, immune pathology, and dysfunction in the lungs

Authors
  • Routhu, Nanda Kishore1, 2
  • Cheedarla, Narayanaiah1, 2
  • Gangadhara, Sailaja1, 2
  • Bollimpelli, Venkata Satish1, 2
  • Boddapati, Arun K.1, 3
  • Shiferaw, Ayalnesh1, 2
  • Rahman, Sheikh Abdul1, 2
  • Sahoo, Anusmita1, 2
  • Edara, Venkata Viswanadh1, 4
  • Lai, Lilin1, 4
  • Floyd, Katharine1, 4
  • Wang, Shelly1
  • Fischinger, Stephanie5
  • Atyeo, Caroline5
  • Shin, Sally A.5
  • Gumber, Sanjeev6
  • Kirejczyk, Shannon6
  • Cohen, Joyce7
  • Jean, Sherrie M.7
  • Wood, Jennifer S.7
  • And 12 more
  • 1 Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
  • 2 Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA
  • 3 Department of Pathology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA
  • 4 Department of Pediatrics, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA 30322, USA
  • 5 Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA
  • 6 Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
  • 7 Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA
  • 8 Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA
  • 9 Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, TX, USA
  • 10 Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX, USA
Type
Published Article
Journal
Immunity
Publication Date
Feb 04, 2021
Volume
54
Issue
3
Pages
542–556
Identifiers
DOI: 10.1016/j.immuni.2021.02.001
PMID: 33631118
PMCID: PMC7859620
Source
PubMed Central
Keywords
License
Unknown

Abstract

Modified vaccinia Ankara (MVA) vector-based vaccines are attractive because of their excellent safety and ability to induce long-lived humoral and cellular immunity in humans. Routhu et al. show that an MVA-based COVID-19 vaccine encoding prefusion-stabilized spike (MVA/S) induces strong neutralizing antibody and CD8+ T cell responses and protects macaques from SARS-CoV2 infection, immunopathology, and infection-induced B cell abnormalities in the lungs.

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