Modification of the U.S.P. dissolution method for the analysis of norethindrone and ethinyl estradiol tablets.
- Published Article
Journal of pharmaceutical sciences
- Publication Date
Mar 01, 1994
A modification of the U.S.P. dissolution method for the quantitation of norethindrone and ethinyl estradiol tablets is proposed. This modification consists of the use of distilled water as the dissolution medium instead of 0.1 N hydrochloric acid (HCl) and/or neutralization of 0.1 N HCl with sodium carbonate prior to analysis. Statistical analysis of the results indicate that there are no significant differences between the dissolution in 0.1 N HCl and the dissolution in distilled water (p < 0.05) for norethindrone and ethinyl estradiol.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/8207685