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Modification of the U.S.P. dissolution method for the analysis of norethindrone and ethinyl estradiol tablets.

Authors
Type
Published Article
Journal
Journal of pharmaceutical sciences
Publication Date
Volume
83
Issue
3
Pages
379–381
Identifiers
PMID: 8207685
Source
Medline
License
Unknown

Abstract

A modification of the U.S.P. dissolution method for the quantitation of norethindrone and ethinyl estradiol tablets is proposed. This modification consists of the use of distilled water as the dissolution medium instead of 0.1 N hydrochloric acid (HCl) and/or neutralization of 0.1 N HCl with sodium carbonate prior to analysis. Statistical analysis of the results indicate that there are no significant differences between the dissolution in 0.1 N HCl and the dissolution in distilled water (p < 0.05) for norethindrone and ethinyl estradiol.

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