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[Modification of the growth of chondrocytes by the action of concanavalin A].

Authors
  • Nagel, N
  • Larno, S
  • Aubery, M
  • Adolphe, M
  • Lechat, P
Type
Published Article
Journal
Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie
Publication Date
Jan 01, 1984
Volume
298
Issue
4
Pages
89–92
Identifiers
PMID: 6424893
Source
Medline
License
Unknown

Abstract

The effects of Concanavalin A have been assessed on the growth of articular cultured chondrocytes. A differential action in relation with cellular density has been observed. Concanavalin A (0.02, 0.2 and 2 micrograms/ml) exerted a stimulating effect on low density cultures, whereas it depressed the cell growth curve with high cell density cultures, especially at the concentration of 2 micrograms/ml. Such a discrepancy in the behaviour of cells related to the density does not seem to have been previously observed with chondrocytes. It could be explained by a modification of the accessibility of Concanavalin A receptors.

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