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[Modes of tissue blood perfusion assessment by microdialysis - a review of current knowledge].

Authors
  • Cibiček, N
Type
Published Article
Journal
Vnitr̆ní lékar̆ství
Publication Date
Jan 01, 2012
Volume
58
Issue
1
Pages
44–51
Identifiers
PMID: 22448700
Source
Medline
License
Unknown

Abstract

Microdialysis is a dynamically evolving method utilized for monitoring of tissue metabolism and barrier function, pharmacological studies and to estimate local blood perfusion in situ. The present review summarizes current knowledge of the last of the aforementioned applications on a characterization and comparison of two approaches used - microdialysis flow-indicator dilution technique and continuous metabolic monitoring. Currently, the use of metabolic indicators, which enable sensitive and complex evaluation of perfusion-induced changes in the tissue, is preferred. Despite the methods numerous advantages the measurement of tissue blood perfusion by microdialysis remains centralized in the area of clinical research, for the present. For wider acceptance and exercise in the routine clinical practice, more validating studies ought to be conducted and situations identified, where microdialysis could replace the current methods.

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