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Modernized low pressure carbonylation methods in batch and flow employing common acids as a CO source.

Authors
  • Brancour, Célia
  • Fukuyama, Takahide
  • Mukai, Yu
  • Skrydstrup, Troels
  • Ryu, Ilhyong
Type
Published Article
Journal
Organic Letters
Publisher
American Chemical Society
Publication Date
Jun 07, 2013
Volume
15
Issue
11
Pages
2794–2797
Identifiers
DOI: 10.1021/ol401092a
PMID: 23697868
Source
Medline
License
Unknown

Abstract

Carbonylation reactions, such as Heck, Sonogashira, and radical carbonylations, were successfully carried out in a "two-chamber reactor" where carbon monoxide was produced ex situ by the Morgan reaction (dehydration of formic acid by sulfuric acid). By a subsequent application in a microflow system using a "tube-in-tube" reactor where gas-permeable Teflon AF2400 was used as the inner tube, it is demonstrated that formic acid/sulfuric acid can be employed concomitantly with an amine base such as triethylamine in the Heck aminocarbonylation of aryl iodide.

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