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Moderate to Severe Thrombocytopenia During Pregnancy: A Single Institutional Experience.

Authors
  • Kim, Bum Jun1
  • Kim, Hyeong Su1
  • Kim, Jung Han1
  • Lee, Keun Young2
  • 1 Division of Hemato-Oncology, Department of Internal Medicine, Kangnam Sacred-Heart Hospital, Hallym University Medical Center, Hallym University College of Medicine, Shingil-ro 1st, Youngdeungpo-Gu, Seoul, 07441 South Korea. , (North Korea)
  • 2 Department of Obstetrics and Gynecology, Kangnam Sacred-Heart Hospital, Hallym University Medical Center, Hallym University College of Medicine, Seoul, South Korea. , (North Korea)
Type
Published Article
Journal
Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion
Publication Date
Dec 01, 2017
Volume
33
Issue
4
Pages
581–585
Identifiers
DOI: 10.1007/s12288-017-0784-1
PMID: 29075073
Source
Medline
Keywords
License
Unknown

Abstract

Most of thrombocytopenic pregnant women present mild decrease of platelet counts and have favorable outcome. However, small portion of these cases can show moderate to severe thrombocytopenia and may increase the risk of bleeding during delivery. We investigated the prevalence, causes, and outcomes of pregnancies complicated by moderate to severe thrombocytopenia. We reviewed medical records of pregnant women who were diagnosed with moderate to severe thrombocytopenia (<100 × 109/L) during their pregnancies. A total of 4822 deliveries were performed and 26 patients (0.54%) with moderate to severe thrombocytopenia were identified. The most common cause of moderate to severe thrombocytopenia was immune thrombocytopenia (ITP) (42.3%), followed by gestational thrombocytopenia (GT) (34.6%). Compared to GT, ITP showed lower platelet counts at presentation (52.4 × 109/L vs. 80.5 × 109/L, P = 0.041). Patients with GT could conduct successful delivery without specific management, and patients with ITP showed favorable delivery outcomes with adequate treatment. In conclusion, the incidence of moderate to severe thrombocytopenia during pregnancy was very low and most common causes were ITP and GT. Patients with moderate to severe thrombocytopenia could have favorable delivery outcomes with adequate treatment.

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