Affordable Access

Models for peripheral B cell development and homeostasis.

Authors
  • Srivastava, Bhaskar
  • Lindsley, R Coleman
  • Nikbakht, Neda
  • Allman, David
Type
Published Article
Journal
Seminars in immunology
Publication Date
Jun 01, 2005
Volume
17
Issue
3
Pages
175–182
Identifiers
PMID: 15826822
Source
Medline
License
Unknown

Abstract

Immature B cells undergo key maturation and selection events after migrating to peripheral lymphoid organs. We will review recent advances in our understanding of the cell populations and molecular interactions underlying the differentiation of immature peripheral B cells into mature marginal zone (MZ) and follicular B cells, and discuss potential mechanisms by which numbers of MZ and follicular B cells are maintained. We will also discuss current controversies over the identity of precursor cells for MZ and follicular B cells, and propose a potentially unifying model for precursor-product relationships in peripheral B cell maturation.

Report this publication

Statistics

Seen <100 times