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Models of triple-stranded polynucleotides with optimised stereochemistry.

Authors
  • S Arnott
  • P J Bond
  • E Selsing
  • P J Smith
Publication Date
Oct 01, 1976
Source
PMC
Disciplines
  • Biology
License
Unknown

Abstract

Detailed models are presented for the triple-stranded polynucleotide helices of poly (U)-poly (A)-poly (U) (two forms), poly (U)-poly d (A) -poly (U), poly d(C)-poly d(I)-poly d(C), poly d(T)-polyd(A)-poly d(T) and poly (I)-poly (A)-poly (I). The models were genrated using a computerized, linked-atom procedure which preserves standard bond lengths, bond anglesand sugar ring conformations, constrains the helices to have the pitches and symmetries observed in X-ray diffraction experiments, and optimises the non-bonded interatomic contacts including hydrogen bonds. The possible biological sigificance of such complexes is discussed.

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