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Modelling upper respiratory tract diseases: getting grips on host-microbe interactions in chronic rhinosinusitis using in vitro technologies

Authors
  • De Rudder, Charlotte1
  • Calatayud Arroyo, Marta1
  • Lebeer, Sarah2
  • Van de Wiele, Tom1
  • 1 Ghent University, Center for Microbial Ecology and Technology, Faculty of Bioscience Engineering, Coupure Links 653, Ghent, B-9000, Belgium , Ghent (Belgium)
  • 2 University of Antwerp, Research Group of Environmental Ecology and Applied Microbiology, Department of Bioscience Engineering, Groenenborgerlaan 171, Antwerp, 2020, Belgium , Antwerp (Belgium)
Type
Published Article
Journal
Microbiome
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Apr 24, 2018
Volume
6
Issue
1
Identifiers
DOI: 10.1186/s40168-018-0462-z
Source
Springer Nature
License
Green

Abstract

Chronic rhinosinusitis (CRS) is a chronic inflammation of the mucosa of the nose and paranasal sinuses affecting approximately 11% of the adult population in Europe. Inadequate immune responses, as well as a dysbiosis of the sinonasal microbiota, have been put forward as aetiological factors of the disease. However, despite the prevalence of this disease, there is no consensus on the aetiology and mechanisms of pathogenesis of CRS. Further research requires in vitro models mimicking the healthy and diseased host environment along with the sinonasal microbiota. This review aims to provide an overview of CRS model systems and proposes in vitro modelling strategies to conduct mechanistic research in an ecological framework on the sinonasal microbiota and its interactions with the host in health and CRS.

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