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Modeling Treatment Strategies to Inform Yaws Eradication.

Authors
  • Holmes, Alex
  • Tildesley, Michael J
  • Solomon, Anthony W
  • Mabey, David C W
  • Sokana, Oliver
  • Marks, Michael
  • Dyson, Louise
Type
Published Article
Journal
Emerging Infectious Diseases
Publisher
Centers For Disease Control and Prevention
Publication Date
Nov 01, 2020
Volume
26
Issue
11
Pages
2685–2693
Identifiers
DOI: 10.3201/eid2611.191491
PMID: 33079046
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Yaws is a neglected tropical disease targeted for eradication by 2030. To achieve eradication, finding and treating asymptomatic infections as well as clinical cases is crucial. The proposed plan, the Morges strategy, involves rounds of total community treatment (i.e., treating the whole population) and total targeted treatment (TTT) (i.e., treating clinical cases and contacts). However, modeling and empirical work suggests asymptomatic infections often are not found in the same households as clinical cases, reducing the utility of household-based contact tracing for a TTT strategy. We use a model fitted to data from the Solomon Islands to predict the likelihood of elimination of transmission under different intervention schemes and levels of systematic nontreatment resulting from the intervention. Our results indicate that implementing additional treatment rounds through total community treatment is more effective than conducting additional rounds of treatment of at-risk persons through TTT.

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