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Modelling human protein interaction networks as metric spaces has potential in disease research and drug target discovery.

Authors
  • Fadhal, Emad
  • Mwambene, Eric C
  • Gamieldien, Junaid
Type
Published Article
Journal
BMC Systems Biology
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Jan 01, 2014
Volume
8
Pages
68–68
Identifiers
DOI: 10.1186/1752-0509-8-68
PMID: 24929653
Source
Medline
License
Unknown

Abstract

Based on the diversity of evidence uncovered, we propose that when considered holistically, proteins located centrally in the human PINs that also have similar functions to existing drug targets are good candidate targets for novel therapeutics. Similarly, since disease pathways are dominated by centrally located proteins, candidates shortlisted in genome scale disease studies can be further prioritized and contextualised based on whether they occupy central positions in the human PINs.

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