Affordable Access

deepdyve-link deepdyve-link
Publisher Website

Modelling human protein interaction networks as metric spaces has potential in disease research and drug target discovery.

Authors
Type
Published Article
Journal
BMC Systems Biology
1752-0509
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
8
Pages
68–68
Identifiers
DOI: 10.1186/1752-0509-8-68
PMID: 24929653
Source
Medline
License
Unknown

Abstract

Based on the diversity of evidence uncovered, we propose that when considered holistically, proteins located centrally in the human PINs that also have similar functions to existing drug targets are good candidate targets for novel therapeutics. Similarly, since disease pathways are dominated by centrally located proteins, candidates shortlisted in genome scale disease studies can be further prioritized and contextualised based on whether they occupy central positions in the human PINs.

Statistics

Seen <100 times