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Modeling Type 1 Diabetes In Vitro Using Human Pluripotent Stem Cells

Authors
  • Leite, Nayara C.1
  • Sintov, Elad1
  • Meissner, Torsten B.2, 3
  • Brehm, Michael A.4
  • Greiner, Dale L.4
  • Harlan, David M.5
  • Melton, Douglas A.1, 6
  • 1 Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA
  • 2 Department of Surgery, Beth Israel Deaconess Medical Center, Boston, 02215 MA, USA
  • 3 Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
  • 4 Program in Molecular Medicine, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, MA 01655, USA
  • 5 Department of Medicine, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, MA 01655, USA
  • 6 Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA
Type
Published Article
Journal
Cell Reports
Publisher
Elsevier
Publication Date
Jul 14, 2020
Volume
32
Issue
2
Pages
107894–107894
Identifiers
DOI: 10.1016/j.celrep.2020.107894
PMID: 32668238
PMCID: PMC7359783
Source
PubMed Central
Keywords
License
Unknown

Abstract

Leite et al. describe an in vitro platform that models features of autoimmune type 1 diabetes using patient-derived endocrine cells and autologous immune cells. This represents a path to developing a model with patient-derived cells to predict and analyze the autoimmune response.

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