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Modeling for Taxol® Separation in a simulated moving bed

Authors
  • Cremasco, Marco Aurelio
  • Starqui, Axel Nicolas
Publication Date
Dec 01, 2010
Source
Scientific Electronic Library Online - Brazil
Keywords
Language
English
License
Unknown
External links

Abstract

This work presents an alternative numerical resolution strategy for a model to describe the dynamic of linear adsorption processes involving multicomponent mixture of taxanes with Taxol® (paclitaxel), a powerful anti-cancer agent, and non-identified impurities, in a Simulated Moving Bed (SMB) system. To solve the model, a hybrid method were used. The liquid concentration inside the particles was found analytically and was related with the liquid bed concentration using Duhamel's theorem. The results from simulation were compared with experimental ones from the literature, showing a good agreement, which demonstrated the applicability of the model and of the hybrid resolution proposed.

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