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Model-Based Prediction to Evaluate Residence Time of Hyaluronic Acid Based Dermal Fillers

Authors
  • Ryu, Hyo-jeong1, 2
  • Kwak, Seong-sung1
  • Rhee, Chang-hoon
  • Yang, Gi-hyeok1,
  • Yun, Hwi-yeol2
  • Kang, Won-ho1, 2
  • 1 (G.-h.Y.)
  • 2 College of Pharmacy, Chungnam National University, Daejeon 34134, Korea
Type
Published Article
Journal
Pharmaceutics
Publisher
MDPI
Publication Date
Jan 21, 2021
Volume
13
Issue
2
Identifiers
DOI: 10.3390/pharmaceutics13020133
PMID: 33494145
PMCID: PMC7909806
Source
PubMed Central
Keywords
Disciplines
  • Article
License
Green

Abstract

Dermal fillers are gel-type substances for nonsurgical medical-device use to achieve facial rejuvenation. Currently, the most widely used skin fillers are hyaluronic-acid-based dermal fillers. This study aimed to explain the change in the volume of injected dermal fillers by developing a mathematical kinetic model for various dermal fillers. The kinetics of the injected fillers were separated by a biphasic phenomenon. We attributed an increase in filler volume to the hydration of hyaluronic acid molecules and injection-site reaction and a decrease in volume to enzyme-mediated degradation. To explain these in vivo characteristics of dermal fillers, we proposed a two-compartment model, divided into a depot compartment (where the filler was injected) and a subcutaneous compartment (an observation compartment where the fillers swell and degrade), assuming that the swelling and degradation occurred in accordance with the swelling and degradation rate constants, respectively. The model was developed using five hyaluronic-acid-based dermal fillers and NONMEM. We determined that the rate-limiting step for the complete degradation of the dermal fillers in vivo was the swelling phase, as described by the swelling rate constant ( K swell ). This study could enable scientists developing novel dermal fillers to predict the in vivo behavior of fillers.

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