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A model-based dose-response meta-analysis of ocular hypotensive agents as a drug development tool to evaluate new therapies in glaucoma.

Authors
  • Raber, Susan1
  • Mandema, Jaap W
  • Li, Hanbin
  • Nickens, Dana J
  • 1 1 Pfizer Inc. , San Diego, California.
Type
Published Article
Journal
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
Publication Date
May 01, 2015
Volume
31
Issue
4
Pages
189–197
Identifiers
DOI: 10.1089/jop.2014.0106
PMID: 25714918
Source
Medline
License
Unknown

Abstract

Model-based meta-analyses for IOP reduction and incidence of hyperemia among prostaglandin analogs are well described by maximal efficacy models and can provide a useful methodology for evaluating glaucoma therapies.

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