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Model for hyperthermia with arrays of magnetic nanoparticles: spatial and time temperature distributions in tumor.

Authors
  • Zablotskii, Vitalii
  • Lunov, Oleg
  • Gómez-Polo, Cristina
Type
Published Article
Journal
Journal of Nanoscience and Nanotechnology
Publisher
American Scientific Publishers
Publication Date
Feb 01, 2010
Volume
10
Issue
2
Pages
690–695
Identifiers
PMID: 20352705
Source
Medline
License
Unknown

Abstract

A square array of micron-sized needles containing magnetic nanoparticles has been studied theoretically as potential systems to deliver heat to tumor tissue for the hyperthermia treatment. The spatiotemporal distributions of temperature in a tumor were calculated for different arrays of microneedles. The resulting temperature distributions are found to be more uniform within the tumor target than those caused by other heating systems. Moreover, the temperature profiles could be tuned by a proper choice of the combination of the system parameters: the needle radius, the spatial needles period, as well as the filling fraction and parameters of magnetic nanoparticles.

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