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Mobilization of intracellular calcium by glucagon and cyclic AMP analogues in isolated rat hepatocytes.

Authors
  • Mauger, J P
  • Claret, M
Type
Published Article
Journal
FEBS Letters
Publisher
Wiley (John Wiley & Sons)
Publication Date
Jan 20, 1986
Volume
195
Issue
1-2
Pages
106–110
Identifiers
PMID: 3002849
Source
Medline
License
Unknown

Abstract

Separate or combined addition of cyclic AMP-dependent and Ca2+-linked hormones to isolated rat hepatocytes suspended in a low Ca2+ medium reduced the total cellular Ca. When the hormones were administered together, their effects were not additive. This suggests that both types of hormones mobilize Ca2+ from a common intracellular pool. In the presence of 1.8 mM extracellular Ca2+, the Ca2+ influx counterbalanced or even exceeded the hormone-induced Ca2+ loss, depending on the ability of the hormones to stimulate the Ca2+ influx.

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