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Mnemonic Similarity Task: A Tool for Assessing Hippocampal Integrity.

Authors
  • Stark, Shauna M1
  • Kirwan, C Brock2
  • Stark, Craig E L3
  • 1 Department of Neurobiology and Behavior, University of California, Irvine, CA, USA.
  • 2 Department of Psychology, Neuroscience Center, Brigham Young University, Provo, UT, USA.
  • 3 Department of Neurobiology and Behavior, University of California, Irvine, CA, USA. Electronic address: [email protected]
Type
Published Article
Journal
Trends in cognitive sciences
Publication Date
Nov 01, 2019
Volume
23
Issue
11
Pages
938–951
Identifiers
DOI: 10.1016/j.tics.2019.08.003
PMID: 31597601
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The hippocampus is critical for learning and memory, relying in part on pattern separation processes supported by the dentate gyrus (DG) to prevent interference from overlapping memory representations. In 2007, we designed the Mnemonic Similarity Task (MST), a modified object recognition memory task, to be highly sensitive to hippocampal function by placing strong demands on pattern separation. The MST is now a widely used behavioral task, repeatedly shown to be sensitive to age-related memory decline, hippocampal connectivity, and hippocampal function, with specificity to the DG. Here, we review the utility of the MST, its relationship to hippocampal function, its utility in detecting hippocampal-based memory alterations across the lifespan, and impairments associated with clinical pathology from a variety of disorders. Copyright © 2019 Elsevier Ltd. All rights reserved.

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