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Loss of Akt activity increases circulating soluble endoglin release in preeclampsia: identification of inter-dependency between Akt-1 and heme oxygenase-1.

Authors
  • Cudmore, Melissa J1
  • Ahmad, Shakil
  • Sissaoui, Samir
  • Ramma, Wenda
  • Ma, Bin
  • Fujisawa, Takeshi
  • Al-Ani, Bahjat
  • Wang, Keqing
  • Cai, Meng
  • Crispi, Fatima
  • Hewett, Peter W
  • Gratacós, Eduard
  • Egginton, Stuart
  • Ahmed, Asif
  • 1 University / BHF Centre for Cardiovascular Science, Queen's Medical Research Institute, College of Medicine and Veterinary Medicine, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.
Type
Published Article
Journal
European Heart Journal
Publisher
Oxford University Press
Publication Date
May 2012
Volume
33
Issue
9
Pages
1150–1158
Identifiers
DOI: 10.1093/eurheartj/ehr065
PMID: 21411816
Source
Medline
License
Unknown

Abstract

The loss of PI3K/Akt and/or HO-1 activity promotes sEng release and positive manipulation of these pathways offers a strategy to circumvent endothelial dysfunction.

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