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[Mixing test for prolonged clotting time: clinical availability and problems].

Authors
Type
Published Article
Journal
Rinsho byori. The Japanese journal of clinical pathology
Publication Date
Volume
57
Issue
10
Pages
1004–1012
Identifiers
PMID: 19928499
Source
Medline
License
Unknown

Abstract

Prothrombin time (PT) and activated partial thromboplastin time (APTT) are basic laboratory tests for diagnosis of bleeding diseases such as congenital hemophilia. In addition, abnormally prolonged clotting times are observed in patients who have inhibitors. Lupus anticoagulant and inhibitors against coagulation factors are two clinically important inhibitors. However, non-specific inhibitors are also observed. Differential diagnosis of these inhibitors is important. Clotting times are also prolonged by artifactitious factors, such as contamination of heparin. Mixing tests are relatively easy and useful methods which potentially differentiate these abnormalities. This article is summarized the causes of prolongation of clotting times and the usefulness of mixing tests for differentiation of the abnormalities.

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