Affordable Access

Mixed lymphocyte reaction in human monoclonal gammopathies.

Authors
  • Carmagnola, A L
  • Boccadoro, M
  • Pileri, A
Type
Published Article
Journal
Experientia
Publication Date
Oct 15, 1983
Volume
39
Issue
10
Pages
1137–1139
Identifiers
PMID: 6225677
Source
Medline
License
Unknown

Abstract

Ten multiple myeloma (MM) and 5 monoclonal gammopathies of undetermined significance (MGUS) were studied. The mixed lymphocyte reaction (MLR) proliferative response was of the same order of magnitude in MM and in MGUS as in normal controls. Normal results were obtained when pathological lymphocytes were used as either responding or stimulating cells. The addition of monoclonal anti-Ia antibodies completely abrogates the proliferative response as in healthy individuals. These results suggest that the immunological mechanisms supposed to be important in MLR are functionally normal in MM and in MGUS, although both the B and T cell lineages are involved in monoclonal gammopathies.

Report this publication

Statistics

Seen <100 times