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A mixed formulation of lactic acid bacteria inhibits trinitrobenzene-sulfonic-acid-induced inflammatory changes of the colon tissue in mice.

Authors
  • Cha, Yun Suk
  • Seo, Jae-Gu
  • Chung, Myung-Jun
  • Cho, Chung Won
  • Youn, Hyun Joo
Type
Published Article
Journal
Journal of microbiology and biotechnology
Publication Date
Oct 01, 2014
Volume
24
Issue
10
Pages
1438–1444
Identifiers
PMID: 24912557
Source
Medline
License
Unknown

Abstract

Lactic acid bacteria (LAB) are probiotics that provide numerous beneficial effects on the host body, especially on the intestine. Combining several strains of LAB, we prepared a formulation containing four different LAB and studied its anti-inflammatory activity both in vitro and in vivo. The formulation significantly reduced NO production from RAW 264.7 cells treated with bacterial lipopolysaccharide, indicating that the formulation might include antiinflammatory activity. The formulation also suppressed inflammatory change induced by trinitrobenzene sulfonic acid (TNBS) in mice, where oral or rectal administration of the formulation protected the colon tissue from the damage by TNBS. Expressions of the IL-6 and FasL genes appeared to be down-regulated by the formulation in TNBS-treated colon tissues, suggesting that the suppression of those genes may be involved in the anti-inflammatory activity of the formulation.

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