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Mixed Cryoglobulinaemia Vasculitis after Persistent Hepatitis C Virus Eradication

Authors
  • Gaudêncio, Margarida1
  • Nogueira, Rui2
  • Afonso, Nuno2, 3
  • 1 Department of Internal Medicine, Hospital Distrital da Figueira da Foz, EPE, Figueira da Foz, Portugal
  • 2 Department of Nephrology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal
  • 3 Faculty of Medicine, University of Coimbra, Coimbra, Portugal
Type
Published Article
Journal
European Journal of Case Reports in Internal Medicine
Publisher
SMC Media Srl
Publication Date
Aug 31, 2021
Volume
8
Issue
8
Identifiers
DOI: 10.12890/2021_002808
PMID: 34527630
PMCID: PMC8436841
Source
PubMed Central
Keywords
Disciplines
  • Articles
License
Unknown

Abstract

Mixed cryoglobulinaemia vasculitis (MCV) is a systemic vasculitis of the small and medium-size vessels caused by active hepatitis C (HCV) infection in >80% of cases. Beuthien et al. presented the first case of MCV with undetectable HCV after 10 months of therapy. In the last few years, more authors have described other cases of symptomatic MCV after 1 year of persistent HCV eradication. Here, we present a case report of a 57-year-old man who developed MCV with renal involvement after 3 years of HCV eradication with interferon therapy. LEARNING POINTS Mixed cryoglobulinaemia can occur after persistent hepatitis C virus eradication. Most cases described in the literature presented mixed cryoglobulinaemia vasculitis (MCV) after 1 year of HCV eradication compared with after 3 years of persistent eradication in our case. The exact mechanism linking HCV and B-cells is not fully understood, but the main factor seems to be the sustained HCV antigenic stimulation of the B-cell compartment.

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