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“Mixed connective tissue disease”: a condition in search of an identity

Authors
  • Alves, Marta R.1
  • Isenberg, David A.2
  • 1 Centro Hospitalar Universitário do Porto,
  • 2 University College of London,
Type
Published Article
Journal
Clinical and Experimental Medicine
Publisher
Springer International Publishing
Publication Date
Mar 04, 2020
Volume
20
Issue
2
Pages
159–166
Identifiers
DOI: 10.1007/s10238-020-00606-7
PMID: 32130548
PMCID: PMC7181542
Source
PubMed Central
Keywords
License
Unknown

Abstract

Mixed connective tissue disease was first described as a new autoimmune rheumatic disease in 1972 based on the claim of a distinct clinical picture associated with anti-RNP antibody positivity. Subsequently, this new entity has divided opinions in the rheumatology community. We have reviewed recent cohort studies with more than 100 patients, comparing the clinical and immunological features, treatment, prognosis and evolution to well-defined autoimmune rheumatic diseases. We also reviewed clinical features of undifferentiated autoimmune rheumatic diseases based on the most recent studies. After gathering and reviewing these data, we discuss whether the designation “mixed connective tissue disease” should be maintained.

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