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Mitral regurgitation: impaired systolic function, eccentric hypertrophy, and increased severity are linked to lower phosphocreatine/ATP ratios in humans.

Authors
  • Conway, M A
  • Bottomley, P A
  • Ouwerkerk, R
  • Radda, G K
  • Rajagopalan, B
Type
Published Article
Journal
Circulation
Publication Date
May 05, 1998
Volume
97
Issue
17
Pages
1716–1723
Identifiers
PMID: 9591766
Source
Medline
License
Unknown

Abstract

These results demonstrate that abnormalities of PCr/ATP in mitral regurgitation are related to disease severity as measured by dimensional indexes of left ventricular dilatation. They suggest that impaired high-energy phosphate metabolism is a marker of hypertrophy and heart failure.

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