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Mitotic memories of gene activity.

Authors
  • Gonzalez, Inma1
  • Molliex, Amandine1
  • Navarro, Pablo2
  • 1 Epigenomics, Proliferation and the Identity of Cells, Department of Developmental and Stem Cell Biology, Institut Pasteur, CNRS, UMR3738, Paris, France. , (France)
  • 2 Epigenomics, Proliferation and the Identity of Cells, Department of Developmental and Stem Cell Biology, Institut Pasteur, CNRS, UMR3738, Paris, France. Electronic address: [email protected] , (France)
Type
Published Article
Journal
Current opinion in cell biology
Publication Date
Jan 13, 2021
Volume
69
Pages
41–47
Identifiers
DOI: 10.1016/j.ceb.2020.12.009
PMID: 33454629
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

When cells enter mitosis, they undergo series of dramatic changes in their structure and function that severely hamper gene regulatory processes and gene transcription. This raises the question of how daughter cells efficiently recapitulate the gene expression profile of their mother such that cell identity can be preserved. Here, we review recent evidence supporting the view that distinct chromatin-associated mechanisms of gene-regulatory inheritance assist daughter cells in the postmitotic reestablishment of gene activity with increased fidelity. Copyright © 2020. Published by Elsevier Ltd.

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